Formulation and Evaluation of Roxithromycin Tablets
نویسنده
چکیده
The objective of the present study is to formulate and evaluate roxithromycin tablets employing roxithromycin (ROX) solid dispersions. Dispersions of ROX in mannitol were prepared by different techniques like physical mixing, melting method, melt solvent method, kneading technique and common solvent method with drug and carrier ratio of 1:1, 1:2, 1:4 and 1:9. ROX tablets were formulated employing 1:4 ratio of ROX-mannitol solid dispersions and their corresponding physical mixtures. The compressed tablets were evaluated for various tablet characteristics including dissolution rate and efficiency. Marked increase in the dissolution rate and efficiency was observed with tablets of dispersions in comparison to tablets formulated with physical mixtures and conventional tablets available commercially. Tablets prepared by dispersion of melt method have shown highest dissolution rate. Dissolution of ROX from these tablets obeyed first-order kinetics.
منابع مشابه
Development and evaluation of regioselective bilayer floating tablets of Atenolol and Lovastatin for biphasic release profile
This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...
متن کاملDevelopment and evaluation of regioselective bilayer floating tablets of Atenolol and Lovastatin for biphasic release profile
This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...
متن کاملFormulation and In Vitro Evaluation of Extended Release Tablets of Paliperidone Using Natural Gums
Paliperidone is a well known dopamine antagonist of the atypical antipsychotic class. In the present study Paliperidone was formulated as ER release tablets using natural and synthetic polymers separately or in combination. The aim of ER release formulation is to reduce the frequency of dosing. Tablets are prepared by direct compression method. The optimized formulations contain Paliperidone as...
متن کاملFormulation and Evaluation of Taste Masked Mouth Dissolving Tablets of Levocetirizine Hydrochloride
Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Levocetirizine and Tulsion-335. Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DRC (Drug Resin Complex) was characterized by infrared...
متن کاملFORMULATION DEVELOPMENT AND EVALUATION OF CLOPIDOGREL FASTDISSOLVING TABLETS
The main objective of present research work is to formulate the Clopidogrel Fast Dissolving tablets. Clopidogrel, an antiplatelet drug, belongs to BCS Class-II and used to control Heart attack, Hypertension by inhibiting Platelet activation and aggregation .The Fast Dissolving tablets of Clopidogrel were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in di...
متن کامل